tag:blogger.com,1999:blog-63498075001030862882024-03-18T23:25:17.877-04:00BIO 4 BeginnersCreated in 2008 to gather Biology learning materials from around the web. Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.comBlogger305125tag:blogger.com,1999:blog-6349807500103086288.post-85099837136261148482014-12-09T23:01:00.001-05:002014-12-09T23:43:43.031-05:00Learn Organic Chemistry - Radical HalogenationIf you are planning to become a biologist, a key required course is organic chemistry and in that class one of the reactions you have to memorize is radical halogenation. In this reaction a halogen atom (e.g. chlorine, bromine, iodine) bonds to a carbon and replaces the hydrogen that was formerly bonded to that carbon. When chlorine is used, the process is called radical chlorination. The music video below was created at Columbia University to help students memorize this reaction.<br />
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<iframe width="560" height="315" src="//www.youtube.com/embed/mipYPUp7qJQ?rel=0" frameborder="0" allowfullscreen></iframe>
<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-31706841721516993052014-04-10T00:19:00.004-04:002014-04-10T10:22:09.947-04:00The first step to a Biology education is usually 2 semesters of ChemistryHere is a free coursera chemistry course to get you up to speed. It is offered by Allison Soult and Kim Woodrum at University of Kentucky. <a href="https://www.coursera.org/course/advancedchemistry">https://www.coursera.org/course/advancedchemistry</a><br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEir7CtVflyiMlXKcCHRuROXteWiYP6YMwwUBEPjauWzBRRM2ee4Co8vtPNiA-7whZOvR0x7qkn5b8kOj5vXJ1fsWIaH3R63Dzlbtl1uQ4b9S89yv18b9BrpxrqhA2b_H_6ud6M38LxpkGM/s1600/Screen+Shot+2014-04-10+at+12.16.03+AM.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEir7CtVflyiMlXKcCHRuROXteWiYP6YMwwUBEPjauWzBRRM2ee4Co8vtPNiA-7whZOvR0x7qkn5b8kOj5vXJ1fsWIaH3R63Dzlbtl1uQ4b9S89yv18b9BrpxrqhA2b_H_6ud6M38LxpkGM/s1600/Screen+Shot+2014-04-10+at+12.16.03+AM.png" height="395" width="640" /></a></div>
<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-15086371756696424812014-04-09T22:28:00.002-04:002014-04-09T22:28:28.670-04:00Darwintoolbox: A briefcase with built in PCR, Centrifuge, and Gel Electrophoresis. <br />
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http://darwintoolbox.com/</div>
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<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-73646154658404963242014-04-09T22:14:00.000-04:002014-04-09T22:21:34.542-04:00Open Textbooks on Biology & Genetics<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoLxo8OZExWKzn8cNpuJNdij4mNYKamkjReVV7pA59gE04Obh-1TzG2-NoffheDmyKxpMAp01ebX1-L4Gg9FlRyUXt2v_49kWqURymluy7LbAurGMd-5fi62TsKXjMSxNQlazLAv9hp0Y/s1600/Screen+Shot+2014-04-09+at+10.13.45+PM.png" imageanchor="1" style="background-color: white; clear: left; font-family: Arial, Helvetica, sans-serif; font-size: 12px; margin-bottom: 1em; margin-right: 1em; text-align: center; word-spacing: 1px;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoLxo8OZExWKzn8cNpuJNdij4mNYKamkjReVV7pA59gE04Obh-1TzG2-NoffheDmyKxpMAp01ebX1-L4Gg9FlRyUXt2v_49kWqURymluy7LbAurGMd-5fi62TsKXjMSxNQlazLAv9hp0Y/s1600/Screen+Shot+2014-04-09+at+10.13.45+PM.png" height="88" width="640" /></a><br />
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<span style="color: #595959; font-family: Century Gothic, Arial, Helvetica, sans-serif;"><span style="font-size: 20px;">Collegeopentextbooks.org has a great list of open text books.</span></span><span style="background-color: transparent; color: #545454; font-family: Arial, Helvetica, sans-serif;"> </span></h2>
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<table border="0" cellpadding="0" cellspacing="0" style="background-color: white; border-collapse: collapse; color: #545454; font-family: Arial, Helvetica, sans-serif; font-size: 12px; margin: 1px; width: 695px; word-spacing: 1px;"><tbody>
<tr><td align="left" valign="center" width="23"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A" width="668"><a href="http://oer.avu.org/handle/123456789/51" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Animal Diversity">Animal Diversity</a> (CC-BY-SA)</td><td width="10"></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" style="background-color: white; border-collapse: collapse; color: #545454; font-family: Arial, Helvetica, sans-serif; font-size: 12px; margin: 1px; width: 695px; word-spacing: 1px;"><tbody>
<tr><td align="left" valign="center" width="23"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A" width="668"><a href="http://virtuallaboratory.colorado.edu/Biofundamentals/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="BioFundamentals: Introductory Molecular Biology">BioFundamentals: Introductory Molecular Biology</a> (CC-BY-SA-NC)</td><td width="10"></td></tr>
<tr><td align="left" valign="center" width="23"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A" width="668"><a href="https://www.boundless.com/biology/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Biology">Biology by Boundless.com</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td width="10"></td></tr>
<tr><td align="left" valign="center" width="23"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A" width="668"><a href="http://oer.avu.org/handle/123456789/32" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Cell Biology and Genetics">Cell Biology and Genetics</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td width="10"></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.ck12.org/flexbook/book/2537" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="CK-12 Biology">CK-12 Biology</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center" width="23"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A" width="668"><a href="http://www.ck12.org/flexr/flexbook/829/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="CK-12 Biology I - Honors">CK-12 Biology I - Honors</a> <span class="hd-contact-2A-b">(CC-BY-NC-SA)</span></td><td width="10"></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://publications.nigms.nih.gov/computinglife/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Computing Life">Computing Life</a> <span class="hd-contact-2A-b">(PD)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oer.avu.org/handle/123456789/33" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Diversity of Algae and Plants">Diversity of Algae and Plants</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oer.avu.org/handle/123456789/34" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Ecology and Environment">Ecology and Environment</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.eol.org/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Encyclopedia of Life">Encyclopedia of Life</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oer.avu.org/handle/123456789/35" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Evolution Biology">Evolution Biology</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.ncbi.nlm.nih.gov/books/NBK22183/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Genes and Disease">Genes and Disease</a> <span class="hd-contact-2A-b">(PD)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://ghr.nlm.nih.gov/handbook" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Help Me Understand Genetics Handbook">Help Me Understand Genetics Handbook</a> <span class="hd-contact-2A-b">(PD)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://en.wikibooks.org/wiki/Human_Physiology" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">Human Physiology</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.vts.intute.ac.uk/tutorial/microbiology/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Internet for Microbiology">Internet for Microbiology</a> <span class="hd-contact-2A-b">(CC-BY-NC)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://publications.nigms.nih.gov/insidethecell/index.html" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Inside the Cell">Inside the Cell – Biology</a> <span class="hd-contact-2A-b">(PD)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="https://www.boundless.com/microbiology/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Microbiology">Microbiology by Boundless.com</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oer.avu.org/handle/123456789/36" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Microbiology and Mycology">Microbiology and Mycology</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oli.web.cmu.edu/openlearning/forstudents/freecourses/biology" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Modern Biology">Modern Biology</a> <span class="hd-contact-2A-b">(CC-NC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.archive.org/details/MolecularBiologyLaboratoryManual_456" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Biology Lab Manual">Molecular Biology Lab Manual</a> (CC-BY)</td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://openlearn.open.ac.uk/course/view.php?id=2645" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Nucleic Acids and Chromatin">Nucleic Acids and Chromatin</a> <span class="hd-contact-2A-b">(CC-NC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.estrellamountain.edu/faculty/farabee/biobk/biobooktoc.html" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">Online Biology Book</a> <span class="hd-contact-2A-b">(Custom)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="https://www.boundless.com/physiology/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Physiology">Physiology by Boundless.com</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://oer.avu.org/handle/123456789/50" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="Plant and Animal Physiology">Plant and Animal Physiology</a> <span class="hd-contact-2A-b">(CC-BY-SA)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://www.learner.org/courses/biology/textbook/index.html" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">Rediscovering Biology</a><strong>1</strong><strong> </strong><span class="hd-contact-2A-b">(Custom)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://science.education.nih.gov/Customers.nsf/HSBrain?OpenForm" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">The Brain: Understanding Neurobiology Through the Study of Addiction</a> (Custom)</td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://publications.nigms.nih.gov/thenewgenetics/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="The New Genetics">The New Genetics</a> (PD)</td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://publications.nigms.nih.gov/structlife/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="The Structures of Life">The Structures of Life</a> <span class="hd-contact-2A-b">(PD)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://openlearn.open.ac.uk/course/view.php?id=2387" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="What do Genes Do?">What Do Genes Do?</a> <span class="hd-contact-2A-b">(CC-BY-NC)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://cnx.org/content/col10639/latest/" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank">What is Biodiversity</a> <span class="hd-contact-2A-b">(CC-BY)</span></td><td></td></tr>
<tr><td align="left" valign="center"><img border="0" src="http://www.collegeopentextbooks.org/images/bullet-3.png" height="11" style="border: 0px solid rgb(199, 199, 199); margin: 7px;" width="10" /></td><td class="hd-contact-2A"><a href="http://openlearn.open.ac.uk/course/view.php?id=2360" style="color: #595959; margin: 0px; padding: 0px; text-decoration: none;" target="_blank" title="What is the Genome Made of?">What is the Genome Made of?</a> <span class="hd-contact-2A-b">(CC-BY-NC)</span></td></tr>
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<span style="font-family: Arial, Helvetica, sans-serif;">Visit collegeopentextbooks.org http://www.collegeopentextbooks.org/opentextbookcontent/open-textbooks-by-subject/biologyandgenetics</span>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-15702470869700002702014-03-26T22:03:00.002-04:002014-03-26T22:03:29.038-04:00Kimball's Free Online Biology Textbookhttp://users.rcn.com/jkimball.ma.ultranet/BiologyPages/F/FallTerm.html<div class="separator" style="clear: both; text-align: center;">
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-77167725622411000432014-03-25T15:37:00.001-04:002014-03-25T15:37:44.303-04:00Excellent Introduction to Fluorescence Microscopy by Nico Stuurman<iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/AhzhOzgYoqw?rel=0" width="420"></iframe>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-19285141179566901612014-03-24T21:50:00.000-04:002014-03-24T21:50:11.352-04:00New genetic discovery could regulate plant growth<div style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 1.4; padding: 0px 0px 17px;">
<i>"The gene, named GIGANTUS1 (or GTS1 for short), is a member of a protein family that controls seed germination, growth, and biomass accumulation in plants. Essentially, it helps plants regulate growth. </i><i style="line-height: 1.4;">"Plants must tightly regulate their cellular functions to grow and cope with constantly changing environmental conditions, but exactly how this occurs is largely unknown," says Simeon Kotchoni, an assistant professor of biology at Rutgers–Camden."</i></div>
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px;">Read more at: </span><a href="http://phys.org/news/2014-03-genetic-discovery-growth.html#jCp" style="background-color: white; color: #313d57; font-family: Arial, Helvetica, sans-serif; font-size: 14px; outline: 0px;">http://phys.org/news/2014-03-genetic-discovery-growth.html#jCp</a>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-21672391236151790102014-03-24T21:47:00.001-04:002014-03-24T21:50:31.864-04:00New technique for identifying gene-enhancer<span style="background-color: white; color: dimgrey; font-family: Arial, Helvetica, sans-serif; font-size: 13px;">With the new SIF-seq technique, mouse embryonic stem cells can be used to identify human embryonic stem cell enhancers even when the human enhancers are not present in the mouse genome. </span><br />
<span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px;">Read more at: </span><a href="http://phys.org/news/2014-03-technique-gene-enhancers.html#jCp" style="background-color: white; color: #313d57; font-family: Arial, Helvetica, sans-serif; font-size: 14px; outline: 0px;">http://phys.org/news/2014-03-technique-gene-enhancers.html#jCp</a>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-69704027567838436952014-03-17T21:53:00.000-04:002014-03-24T21:53:38.938-04:00Fruit flies help uncover tumor-preventing protein complex<figure class="image-block" style="background-color: white; border-bottom-color: rgb(198, 198, 198); border-bottom-style: solid; border-bottom-width: 1px; font-family: Arial, Helvetica, sans-serif; font-size: 15px; margin: 0px; padding: 0px 20px 0px 0px;"><div class="image-block-ins" style="font-size: 14px; margin: 0px; padding: 0px; position: relative;">
<img alt="Fruit flies help uncover tumor-preventing protein complex" src="http://cdn.phys.org/newman/gfx/news/2014/fruitflieshe.jpg" style="border: 0px; display: block; margin: 0px; padding: 0px; position: relative; z-index: 1;" /></div>
<figcaption class="image-block-caption" style="color: dimgrey; font-size: 13px; margin: 0px; padding: 9px 0px 5px;">Pictured here are ectopic neural stem cells formed from dedifferentiation of progenitor cells upon loss of both HDAC3 and Snr1 (a subunit of the Brahma complex). Credit: Chwee Tat Koe</figcaption></figure><section class="article-block" style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 1.4; margin: 0px; padding: 28px 0px 0px 55px; position: relative;"><div style="line-height: 1.4; padding: 0px 0px 17px;">
<i>A team of researchers from Duke-NUS Graduate Medical School have discovered a protein complex that disrupts the process known as dedifferentiation, known to promote tumor development.</i></div>
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<i>Dedifferentiation (reversion) is a process that leads progenitor or <a class="textTag" href="http://phys.org/tags/mature+cells/" rel="tag" style="color: #313d57; outline: 0px;">mature cells</a> to become 'ectopic neural stem cells' which causes tumors. By detecting this protein complex, Duke-NUS researchers have shed light on a process that inhibits <a class="textTag" href="http://phys.org/tags/tumor+development/" rel="tag" style="color: #313d57; outline: 0px;">tumor development</a> and gives hope for the discovery of therapies and treatments that target tumor prevention through this pathway.</i></div>
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http://phys.org/news/2014-03-fruit-flies-uncover-tumor-preventing-protein.htmlEric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-23250945157558849662014-03-13T22:13:00.003-04:002014-03-13T22:21:08.589-04:00Arduino Sensor Kits by Manylabshttp://store.manylabs.org/<br />
https://www.kickstarter.com/projects/petersand/manylabs-sensors-for-students?ref=category<br />
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<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-55802465452268739622014-03-07T22:46:00.002-05:002014-03-07T22:46:39.423-05:00A kickstarter for experiments - experiment.com<div class="separator" style="clear: both; text-align: center;">
<span style="text-align: start;">https://experiment.com/home</span></div>
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<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-79197783878220047882014-03-01T12:38:00.003-05:002014-03-01T12:38:35.198-05:00Researchers at Princeton have deciphered the 3-D structure of RNase L, an enzyme that slices through RNA and is a first responder in the innate immune system.<div class="image-block-ins" style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px; margin: 0px; padding: 0px; position: relative;">
<span style="font-family: Times; font-size: small;">Link to the Princeton paper:</span><br /><span style="font-family: Arial, Helvetica, sans-serif; font-size: small;"><span style="font-size: 14px;"><a href="http://www.sciencemag.org/content/early/2014/02/26/science.1249845">http://www.sciencemag.org/content/early/2014/02/26/science.1249845</a></span></span></div>
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<img alt="It slices, it dices, and it protects the body from harm (Science)" src="http://cdn.physorg.com/newman/gfx/news/2014/itslicesitdi.jpg" style="border: 0px; display: block; margin: 0px; padding: 0px; position: relative; z-index: 1;" /></div>
<figcaption class="image-block-caption" style="background-color: white; color: dimgrey; font-family: Arial, Helvetica, sans-serif; font-size: 13px; margin: 0px; padding: 9px 0px 5px;"><i>The structure contains two subunits, represented in red as two parts of a pair of scissors. Illustration by Sneha Rath. Inset courtesy of <span style="margin: 0px; padding: 0px;">Science</span>. Credit: Sneha Rath</i></figcaption><div style="background-color: white; padding: 0px 0px 17px;">
<i style="font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 1.4;">"</i><span style="font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14px; line-height: 19.600000381469727px;"><i>An essential weapon in the body's fight against infection has come into sharper view. Researchers at Princeton University have discovered the 3D structure of an enzyme that cuts to ribbons the genetic material of viruses and helps defend against bacteria. </i></span></span><i style="font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 1.4;">The Princeton team's work has also led to new insights on the enzyme's function. <span style="line-height: 1.4;">The enzyme is an important player in the </span><a class="textTag" href="http://phys.org/tags/innate+immune+system/" rel="tag" style="color: #313d57; line-height: 1.4; outline: 0px;">innate immune system</a><span style="line-height: 1.4;">, a rapid and broad response to invaders that includes the production of a molecule called interferon. Interferon relays distress signals from infected cells to neighboring healthy cells, thereby activating RNase L to turn on its ability to slice through RNA, a type of </span><a class="textTag" href="http://phys.org/tags/genetic+material/" rel="tag" style="color: #313d57; line-height: 1.4; outline: 0px;">genetic material</a><span style="line-height: 1.4;"> that is similar to DNA. The result is new cells armed for destruction of the foreign RNA. </span><span style="line-height: 1.4;">The 3D structure uncovered by Korennykh and his team consists of two nearly identical subunits called protomers. The researchers found that one protomer finds and attaches to the RNA, while the other protomer snips it. </span><span style="line-height: 1.4;">The initial protomer latches onto one of the four "letters" that make up the RNA code, in particular, the "U," which stands for a component of RNA called uridine. The other protomer "counts" RNA letters starting from the U, skips exactly one letter, then cuts the RNA. </span><span style="line-height: 1.4;">Although the enzyme can slice any RNA, even that of the body's own cells, it only does so when activated by interferon. </span><span style="line-height: 1.4;">"We were surprised to find that the two protomers were identical but have different roles, one binding and one slicing," Korennykh said. "Enzymes usually have distinct sites that bind the substrate and catalyze reactions. In the case of RNase L, it appears that the same exact protein surface can do both binding and catalysis. One RNase L subunit randomly adopts a binding role, whereas the other identical subunit has no other choice but to do catalysis."</span></i></div>
- Quoted from <a href="http://phys.org/news/2014-03-slices-dices-body.html#jCp" style="background-color: white; color: #313d57; font-family: Arial, Helvetica, sans-serif; font-size: 14px; outline: 0px;">http://phys.org/news/2014-03-slices-dices-body.html#jCp</a>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-73835615319870218542014-03-01T12:26:00.004-05:002014-03-01T12:28:46.177-05:00The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet<div class="separator" style="clear: both; text-align: center;">
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(A) Kaplan-Meier survival curves for mice fed either a standard diet (SD) or high-fat diet (HFD)</div>
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supplemented without or with SRT1720 (SDSRT1720, HFD-SRT1720). </div>
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<b>Blue is a standard diet. Red is a standard diet plus SRT1720. Purple is a high-fat diet. </b><b>Orange is a high-fat diet plus SRT1720.</b></div>
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ACCESS TO THE FULL PDF OF THE PAPER IS FREE AND FOUND HERE:<br />
<a href="http://download.cell.com/cell-reports/pdf/PIIS2211124714000655.pdf?intermediate=true">http://download.cell.com/cell-reports/pdf/PIIS2211124714000655.pdf?intermediate=true</a><br />
<br />
<b>Cell Reports, 27 February 2014</b><br />
Copyright © 2014 The Authors<br />
10.1016/j.celrep.2014.01.031 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.<br />
<b><br /></b>
<b>Authors</b><br />
Sarah J. Mitchell,Alejandro Martin-Montalvo,Evi M. Mercken,Hector H. Palacios,Theresa M. Ward,Gelareh Abulwerdi,Robin K. Minor,George P. Vlasuk,James L. Ellis,David A. Sinclair,John Dawson,David B. Allison,Yongqing Zhang,Kevin G. Becker,Michel Bernier,Rafael de Cabosend emailSee Affiliations<br />
<b><br /></b>
<b>Highlights</b><br />
SRT1720 supplementation extends mean lifespan of mice fed a standard diet<br />
SRT1720 improves healthspan of mice fed a standard diet<br />
SRT1720 reduces the age-associated increase in risk factors for metabolic disease<br />
SRT1720 supplementation confers antiinflammatory properties in target tissues<br />
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<b>Summary</b><br />
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, improves metabolism and confers protection against physiological and cognitive disturbances in old age. SRT1720 is a specific SIRT1 activator that has health and lifespan benefits in adult mice fed a high-fat diet. We found extension in lifespan, delayed onset of age-related metabolic diseases, and improved general health in mice fed a standard diet after SRT1720 supplementation. Inhibition of proinflammatory gene expression in both liver and muscle of SRT1720-treated animals was noted. SRT1720 lowered the phosphorylation of NF-κB pathway regulators in vitro only when SIRT1 was functionally present. Combined with our previous work, the current study further supports the beneficial effects of SRT1720 on health across the lifespan in mice.Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-40627584066455510012014-02-28T15:05:00.001-05:002014-02-28T15:48:40.931-05:00Wyss Institute discovery: New method identifies working copies of genes in human cells<iframe allowfullscreen="" height="281" mozallowfullscreen="" src="//player.vimeo.com/video/87195717" webkitallowfullscreen="" width="500"></iframe><br />
<span style="background-color: white; color: grey; font-family: sans-serif; font-size: x-small; line-height: 19.5px;"><i>"George Church and Evan Daugharthy explain how fluorescent in situ sequencing works and describe potential applications, such as new diagnostics that could spot the earliest signs of disease. Credit: Wyss Institute, Allen Institute for Brain Science, and Harvard Medical School."</i></span><br />
<br />
<iframe allowfullscreen="" height="281" mozallowfullscreen="" src="//player.vimeo.com/video/87224803" webkitallowfullscreen="" width="500"></iframe><br />
<span style="background-color: white; color: grey; font-family: sans-serif; font-size: x-small; line-height: 19.5px;"><i>"In this video, “letters,” or bases, are added to RNAs throughout the cell during fluorescent in situ sequencing, causing the RNAs to flash a specific color that indicates which base has been added (0:00 – 0:05). The sequence of colors, represented abstractly here as a growing stack of colored balls (0:08-0:16), reveals the base sequence. Credit: Wyss Institute and Harvard Medical School."</i></span><br />
<br />
<span style="color: grey; font-family: sans-serif; font-size: x-small;"><span style="line-height: 19.5px;"><i><iframe allowfullscreen="" frameborder="0" height="281" mozallowfullscreen="" src="//player.vimeo.com/video/87224802" webkitallowfullscreen="" width="500"></iframe> <a href="http://vimeo.com/87224802">FISSEQ: Close-up to landscape</a> from <a href="http://vimeo.com/wyssinstitute">Wyss Institute</a> on <a href="https://vimeo.com/">Vimeo</a>.</i></span></span><br />
<i style="color: grey; font-family: sans-serif; font-size: small; line-height: 19.5px;">"Watch here to see how fluorescent in situ sequencing enables scientists to simultaneously determine the base sequence and location of hundreds of RNAs in a single cell or across a landscape of cells."</i><br />
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<br />
Below is quoted from official press release from the Wyss Institute for the full article visit... <a href="http://wyss.harvard.edu/viewpressrelease/143/">http://wyss.harvard.edu/viewpressrelease/143/</a><br />
<br />
<b><i>A bird's eye view of cellular RNAs</i></b><br />
<i>Date: Feb 27, 2014</i><br />
<i> In biology, as in real estate, location matters. Working copies of active genes — called messenger RNAs or mRNAs — are positioned strategically throughout living tissues, and their location often helps regulate how cells and tissues grow and develop. But to analyze many mRNAs simultaneously, scientists have had to grind cells to a pulp, which left them no good way to pinpoint where those mRNAs sat within the cell. </i><i>Now a team at the Wyss Institute of Biologically Inspired Engineering at Harvard University and Harvard Medical School, in collaboration with the Allen Institute for Brain Science, has developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells — all while determining the sequence of letters, or bases, that identify them and reveal what they do.</i><br />
<i><br /></i>
<i>The method, called fluorescent in situ RNA sequencing (FISSEQ), could lead to earlier cancer diagnosis by revealing molecular changes that drive cancer in seemingly healthy tissue. It could track cancer mutations and how they respond to modern targeted therapies, and uncover targets for safer and more effective ones. </i><br />
<i><b><br /></b></i>
<i><b>Healthy human cells typically turn on nearly half of their 20,000 genes at any given time, and they choose those genes carefully to produce the desired cellular responses. Moreover, cells can dial gene expression up or down, adjusting to produce anywhere from a few working copies of a gene to several thousand.</b></i><br />
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<i>To solve that problem, the researchers pioneered an unconventional method to visualize tiny objects inside cells.<b> It works like an urban postal system.</b> If a postmaster tried to identify each home in her city by color, she would quickly run out of colors as new homes were built, resulting in undelivered mail. Instead, postmasters keep track of each home by assigning it a unique address.</i><br />
<i><br /></i>
<i><b>The researchers realized they could assign each RNA in the cell a unique address: the sequence of "letters," or bases, in the RNA molecule itself. </b>And they figured they could read the address using methods akin to next-generation DNA sequencing, a set of high-speed genome sequencing methods Church helped develop in the early 2000s. </i><i>In next-gen sequencing, scientists grind up tissue, extract its DNA, break the DNA into pieces, then dilute those pieces enough so that each piece of DNA sticks to a separate spot on a glass slide. They use enzymes and four different fluorescent dyes — one each for each of the four "letters," or bases — to make the DNA flash a sequence of colors that reveals its sequence.</i><br />
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<i><b>By analogy, the scientists sought to fix RNA in place in the cell, make a tiny ball with many matching DNA replicas of each RNA, then adapt next-gen DNA sequencing so it worked in fixed cells. The four flashing colors would reveal the base sequence of each replica DNA, which would tell them the base sequence of the matching RNA from which it was derived. And those sequences would in theory provide an unlimited number of unique addresses — one for each of the original RNAs.</b></i><br />
<i><br /></i>
<i>The scientists struggled at first to visualize the flashing lights of individual balls of replica DNA from a distance where the whole landscape of the tissue remained in view. <b>They succeeded by selectively turning on just a fraction of those flashing dots at any given time, so they could distinguish single balls of replica DNA flashing across the cellular landscape.</b></i><br />
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<i>The strategy would only work, however, if they could actually read enough of the base sequence to provide a unique address. At first they could not determine more than six bases in the replica DNA, which did not provide enough unique addresses to identify individual genes in the human genome. That's when Evan Daugharthy, a graduate student at Harvard Medical School, stepped in.</i><br />
<i><br /></i>
<i><b>FISSEQ at Work</b></i><br />
<i>Daugharthy first devised an algorithm to locate the sequence of the replica DNA with the known sequence of genes in the human genome. Flashing lights that did not correspond to a real gene were erased from the image. </i><i>Then Daugharthy hacked a commercial DNA sequencing kit, which enabled the team to sequence 30 bases, more than enough to provide each replica DNA with a unique address. In this way the team could create a composite image representing the sequence, and location, of RNA corresponding to every gene in the human genome. </i><i><b>Lee, Daugharthy and their colleagues then tested the method to detect the genes skin cells turn on as they multiply and migrate to heal a simulated wound in a petri dish. Cells growing into the wound had 12 genes that were activated much more or much less than nearby cells sitting idly on the sidelines. Similar experiments could identify new markers of diseased tissue or new targets for targeted molecular therapies.</b></i><br />
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<i><b>"What George's team has accomplished is a technological tour de force," said Wyss Institute Founding Director Don Ingber, M.D., Ph.D. "By spotting incredibly subtle but incredibly important changes in gene expression and precisely defining their position inside the cell, they have helped open the door to a new age of cellular diagnostics."</b></i><br />
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-71449202115141437352014-02-28T14:47:00.001-05:002014-02-28T14:47:24.082-05:00MIT scientists show tree branch to be effective water purifier<h1 class="st_headline " style="font-family: Roboto;">
<span style="color: #6d6d6d;">A suitable water filter is already growing in most forests.</span></h1>
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Sapwood filter (MIT)</div>
<span style="font-family: Roboto;"><br />Read more: <a href="http://www.upi.com/Science_News/2014/02/27/MIT-scientists-show-tree-branch-to-be-effective-water-purifier/7811393531999/#ixzz2ueE2QyVM" style="color: #003399; text-decoration: none;">http://www.upi.com/Science_News/2014/02/27/MIT-scientists-show-tree-branch-to-be-effective-water-purifier/7811393531999/#ixzz2ueE2QyVM</a></span><br />
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<b>Download the research paper:</b></h2>
<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089934">http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089934</a><br />
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Water Filtration Using Plant Xylem</h1>
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<li style="color: #666666; float: left; list-style-type: none; margin: 0px 4px 0px 0px; padding: 0px;">Published: February 26, 2014</li>
<li style="color: #666666; float: left; list-style-type: disc; margin: 0px 4px 0px 20px; padding: 0px;">DOI: 10.1371/journal.pone.0089934</li>
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-11402644242549394362014-02-28T14:42:00.001-05:002014-02-28T14:43:37.226-05:00A reminder: If homework ever seems too tough, or the math seems too hard to get through... remind yourself of your mission and watch this video again. Humanity needs scientists! <iframe allowfullscreen="" frameborder="0" height="315" mozallowfullscreen="" scrolling="no" src="http://embed.ted.com/talks/e_o_wilson_advice_to_young_scientists.html" webkitallowfullscreen="" width="560"></iframe>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-1604450429363967322014-02-28T14:09:00.000-05:002014-02-28T14:09:08.537-05:00HHMI - The 2013 Holiday Lectures on Science are now available via on-demand streaming!<a class="" href="http://media.hhmi.org/hl_unedited/13Lect1.html" style="-webkit-text-stroke-width: 0px; background-color: white; border: 0px; color: #00488c; font-family: 'ITCFranklinGothicW01-Md 812695', sans-serif; font-size: 18px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 25.200000762939453px; margin: 0px; orphans: auto; outline: 0px; padding: 0px; text-align: start; text-decoration: none; text-indent: 0px; text-transform: none; vertical-align: baseline; white-space: normal; widows: auto; word-spacing: 0px;"><img alt="" height="215" src="http://www.hhmi.org/sites/default/files/styles/biointeractive_summary/public/Biointeractive/Images/HL_content-page.jpg?itok=aULiJj8s" style="border: none; float: left; font-family: inherit; font-size: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 15px 12px 0px; outline: 0px; padding: 0px; vertical-align: bottom;" typeof="foaf:Image" width="215" /></a><br />
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<span style="font-family: 'ITCFranklinGothicW01-Bk 812647', sans-serif; font-size: 18px; line-height: 25.200000762939453px;">The 2013 Holiday Lectures on Science are now available via on-demand streaming!</span></h2>
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The 2013 Holiday Lectures are now available</div>
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via on-demand streaming! Click the thumbnail</div>
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or <a href="http://media.hhmi.org/hl_unedited/13Lect1.html">follow this link</a> to view!</div>
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<span style="font-family: ITCFranklinGothicW01-Bk 812647, sans-serif; font-size: medium;"><span style="line-height: 25.200000762939453px;"><i>"Sixty years after James Watson and Francis Crick revealed the structure of the DNA double helix and only a decade after scientists published the first complete read-through of all three billion DNA bases in the human genome, the ability to routinely sequence and analyze individual genomes is revolutionizing the practice of medicine—from how diseases are first diagnosed to how they are treated and managed.</i></span></span></div>
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<span style="font-family: ITCFranklinGothicW01-Bk 812647, sans-serif; font-size: medium;"><span style="line-height: 25.200000762939453px;"><i>In the 2013 Holiday Lectures on Science, Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center and Christopher A. Walsh of Boston Children’s Hospital will reveal the breathtaking pace of discoveries into the genetic causes of various types of cancers and diseases of the nervous system, and discuss the impact of those discoveries on our understanding of normal human development and disease."</i></span></span></div>
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-66038906391862497752014-02-28T14:01:00.002-05:002014-02-28T14:01:54.871-05:00HHMI and Tangled Bank Studio's presents: Your Inner Fish (a story about our biological ancestors and what we inherited from them)<object classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" codebase="http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=9,0,47,0" height="270" id="flashObj" width="480"><param name="movie" value="http://c.brightcove.com/services/viewer/federated_f9?isVid=1&isUI=1" /><param name="bgcolor" value="#FFFFFF" /><param name="flashVars" value="videoId=3091961687001&playerID=748768175001&playerKey=AQ~~,AAAArZFA_pE~,D1__qX58jepyn9zojJ2LYUEMlOHX-HLh&domain=embed&dynamicStreaming=true" /><param name="base" value="http://admin.brightcove.com" /><param name="seamlesstabbing" value="false" /><param name="allowFullScreen" value="true" /><param name="swLiveConnect" value="true" /><param name="allowScriptAccess" value="always" /><embed src="http://c.brightcove.com/services/viewer/federated_f9?isVid=1&isUI=1" bgcolor="#FFFFFF" flashVars="videoId=3091961687001&playerID=748768175001&playerKey=AQ~~,AAAArZFA_pE~,D1__qX58jepyn9zojJ2LYUEMlOHX-HLh&domain=embed&dynamicStreaming=true" base="http://admin.brightcove.com" name="flashObj" width="480" height="270" seamlesstabbing="false" type="application/x-shockwave-flash" allowFullScreen="true" allowScriptAccess="always" swLiveConnect="true" pluginspage="http://www.macromedia.com/shockwave/download/index.cgi?P1_Prod_Version=ShockwaveFlash"></embed></object>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-30559564400190584812014-02-28T13:17:00.000-05:002014-02-28T13:17:22.804-05:00The Allen Institute for Brain Science: Atlas of Human Brain, Mouse Brain, Spinal Cord, Primate Brain. <div class="topicBlock_Row2" style="font-family: arial, helvetica, sans-serif; font-size: 12px; margin-left: 15px;">
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The Allen Institute for Brain Science: Online Public Resources</div>
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Our major atlas initiatives integrate extensive genomic and anatomic data, yielding uniquely comprehensive resources that provide researchers with a critical window into the biology<br />underlying nervous system function.In addition to our comprehensive atlas initiatives, we take on other significant projects related to the study and understanding of the brain. These projects include a variety of government-funded research programs and unique collaborations with other partner organizations and scientists who share our desire to fuel new discoveries in neuroscience through an open data model.<br />
Our entire suite of online public resources—each a groundbreaking creation—is available through the <a href="http://brain-map.org/" target="_blank">Allen Brain Atlas</a> data portal. The specific resources include:<br />
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<ul style="margin-bottom: 0px;">
<li><a href="http://www.alleninstitute.org/science/public_resources/atlases/mouse_atlas.html">ALLEN <strong>Mouse Brain Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/atlases/human_atlas.html">ALLEN <strong>Human Brain Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/atlases/connectivity_atlas.html">ALLEN <strong>Mouse Brain Connectivity Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/atlases/dev_mouse_atlas.html">ALLEN <strong>Developing Mouse Brain Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/atlases/spinal_cord_atlas.html">ALLEN <strong>Spinal Cord Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/brainspan.html"><strong>BrainSpan Atlas of the Developing Human Brain</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/nhp_atlas.html"><strong>NIH Blueprint Non-Human Primate (NHP) Atlas</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/ivy_glioblastoma_atlas.html"><strong>Ivy Glioblastoma Atlas Project</strong></a></li>
<li><a href="http://www.alleninstitute.org/science/public_resources/sleep_study.html"><strong>Sleep Study</strong></a></li>
<li><strong><a href="http://www.alleninstitute.org/science/public_resources/mouse_diversity_study.html">Mouse Diversity Study</a></strong></li>
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-3172878228986078092014-02-28T13:08:00.000-05:002014-02-28T13:08:05.219-05:00A 3D atlas of a mouse brain - Mouse Connectome Project - Free Access<span style="background-color: white; font-size: 12px; line-height: 21.600000381469727px;"><span style="color: #333333; font-family: Arial, Helvetica, sans-serif;"><i><a href="http://www.mouseconnectome.org/">http://www.mouseconnectome.org/</a></i></span></span><br />
<i><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 21.600000381469727px;">The Mouse Connectome Project (MCP) aims to create a three-dimensional digital connectome atlas of the C57Black/6J mouse brain. The site will offer a catalog of neural tracer injection cases, which will be updated continuously to eventually cover the entire brain. Serial sections of each case are available to view at 10x magnification in the interactive </span><a href="http://www.mouseconnectome.org/iConnectome/" style="background-color: white; border: 0px; color: #50b348; cursor: pointer; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 21.600000381469727px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_blank" title="iConnectome"><span style="border: 0px; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">iConnectome viewer</span></a><span style="background-color: white; color: #333333; font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 21.600000381469727px;">.</span></i><br />
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<i>iConnectome Maps</i></h4>
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<i>The cortical map viewer provides a fast and easy way to view projection patterns for all injections featured in the iConnectome browser. In the viewer, raw data from each case has been graphically rendered in the common space of the Allen Reference Atlas, allowing users to directly compare input and output characteristics for different regions.<a href="http://www.mouseconnectome.org/CorticalMap/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_self" title="iConnectome Maps">Go to iConnectome Maps ></a></i></div>
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<a href="http://www.mouseconnectome.org/CorticalMap/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_self" title="iConnectome Maps"><i><img alt="iConnectome Maps" class="aligncenter size-full wp-image-1124" height="300" src="http://www.mouseconnectome.org/wp-content/uploads/2010/10/iConnectome_Maps-thumbnail.png" style="border: 0px; display: block; margin: 5px; outline: 0px;" title="iConnectome_Maps-thumbnail" width="228" /></i></a></div>
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<i>iConnectome Viewer</i></h4>
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<i>Currently, 161 cases (315 injection sites, 600 pathways) are now available to explore in<a href="http://www.mouseconnectome.org/iConnectome/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_blank" title="iConnectome"><span style="border: 0px; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">iConnectome</span></a>. The data sets feature 6 layers: 4 tracers (PHAL, CTb, BDA, FG), nissl brightfield, and ABA Reference atlas. Each of which may be turned on, off, or adjusted for transparency. Split-window and tab-window features are available for comparing multiple data sets. <a href="http://www.mouseconnectome.org/iConnectome/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_self" title="iConnectome">Go to iConnectome ></a></i></div>
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<i><a href="http://www.mouseconnectome.org/iConnectome/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_blank"><img alt="" class="aligncenter size-full wp-image-804" height="180" src="http://www.mouseconnectome.org/wp-content/uploads/2011/09/viewerImage_2.png" style="border: 0px; display: block; margin: 5px; outline: 0px;" title="viewerImage_2" width="226" /></a><a href="http://www.mouseconnectome.org/iConnectome/" style="border: 0px; color: #50b348; cursor: pointer; font-family: inherit; font-weight: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;" target="_blank" title="iConnectome"><img alt="" height="124" src="http://www.mouseconnectome.org/wp-content/uploads/2011/09/viewerImage_3-300x164.png" style="border: 0px; margin: 5px; outline: 0px;" width="226" /></a></i></div>
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<i>Thumbnail Gallery</i></h4>
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<i>The Thumbnail Gallery provides a quick overview of representative labeling for each case in the iConnectome viewer. Captioned images of the injection sites, BDA/FG labeling, and PHA-L/CTb labeling can be viewed here for any particular case. The gallery can be accessed by clicking on the magnifying glass symbol <img alt="" class="alignnone size-full wp-image-981" height="19" src="http://www.mouseconnectome.org/wp-content/uploads/2010/10/mag.jpg" style="border: 0px; outline: 0px;" title="mag" width="19" /> next to the case number in the iConnectome search page.</i></div>
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<img alt="Thumbnail Gallery" class="alignleft size-medium wp-image-867" height="228" src="http://www.mouseconnectome.org/wp-content/uploads/2011/09/thumbnailgallery_1-300x228.png" style="border: 0px; float: left; margin: 5px 1em 5px 0px; outline: 0px;" title="Thumbnail Gallery" width="300" /></div>
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Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-76267529676420971252014-02-28T12:09:00.000-05:002014-02-28T12:09:59.897-05:00Free Webinar on Cancer Immunotherapy! Register now. It will be held March 20th with Dr. Jedd Wolchok Chief, Melanoma & Immunotherapeutics Service Memorial Sloan-Kettering Cancer Center, and Dr. Tibor Keler from Celidex Therapudics<b>Quoted from: <a href="http://www.the-scientist.com/?articles.view/articleNo/39240/title/Tools-and-Strategies-Driving-Cancer-Immunotherapy/">http://www.the-scientist.com/?articles.view/articleNo/39240/title/Tools-and-Strategies-Driving-Cancer-Immunotherapy/</a></b><br />
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<b>"Tools and Strategies Driving Cancer Immunotherapy</b><br />
The Scientist brings together a panel of experts who will delve into the hope and hype in an effort to educate the audience about the new findings in cancer immunotherapy."<br />
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<a href="http://w.on24.com/r.htm?e=757249&s=1&k=AA6ECFA0AB6F46E884ED5AC9DE3B32F5" style="-webkit-transition: all 0.1s ease-in-out; color: #2d86cb; text-decoration: none; transition: all 0.1s ease-in-out;" target="_blank"><span class="imageBlock" style="display: inline-block; float: left; margin: 0px; padding-right: 1em; width: 640px;"><img alt="" src="http://www.the-scientist.com/images/Webinars/TS_Cancer_640x150.jpg" height="150" title="" width="640" /></span></a></div>
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<strong><i>FREE Webinar</i></strong></div>
<div style="background-color: white; color: #333333; font-family: Verdana, Tahoma, Helvetica, Arial, sans-serif; font-size: 12px; line-height: 16.5px; margin-bottom: 14px; margin-top: 14px;">
<i><strong>Thursday March 20, 2014</strong><br /><strong>2:30 - 4:00 p.m. Eastern Time</strong><br /><a href="http://w.on24.com/r.htm?e=757249&s=1&k=AA6ECFA0AB6F46E884ED5AC9DE3B32F5" style="-webkit-transition: all 0.1s ease-in-out; color: #2d86cb; text-decoration: none; transition: all 0.1s ease-in-out;" target="_blank"><strong>Register Now</strong></a></i></div>
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<i>A number of labs in the pharma/biotech industry and in academia are now focusing their efforts on new ways to modulate the immune system to target cancer. Advances, both in understanding immune pathways and in developing tools to target and exploit these pathways, have led to remarkable progress in this relatively new field. The Scientist brings together a panel of experts who will delve into the hope and hype in an effort to educate the audience about the new findings in cancer immunotherapy. Attendees can interact with the experts during the live webinar by asking questions and sharing their experiences on this topic.</i></div>
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<i>Topics to be covered:</i></div>
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<li><i>Basic concepts underlying immunomodulation for oncology</i></li>
<li><i>New drug entities: immunomodulatory agents, vaccines, monoclonal antibodies, and more</i></li>
<li><i>Challenges in drug development</i></li>
<li><i>New tools for screening and validation</i></li>
<li><i>Use of biomarkers for targeted therapies</i></li>
</ul>
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<a href="http://w.on24.com/r.htm?e=757249&s=1&k=AA6ECFA0AB6F46E884ED5AC9DE3B32F5" style="-webkit-transition: all 0.1s ease-in-out; color: #2d86cb; text-decoration: none; transition: all 0.1s ease-in-out;" target="_blank"><strong><i>Register Now</i></strong></a></div>
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<span style="color: #cb2d2d;"><i>Meet the Speakers:</i></span></h3>
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<span class="imageBlock" style="display: inline-block; float: left; padding-right: 1em; width: 101px;"><i><img alt="" src="http://www.the-scientist.com/images/Webinars/Wolchokhead.jpg" height="100" title="" width="101" /></i></span><i>Dr. Jedd Wolchok<br />Chief, Melanoma & Immunotherapeutics Service<br />Memorial Sloan-Kettering Cancer Center</i></div>
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<span class="imageBlock" style="display: inline-block; float: left; padding-right: 1em; width: 99px;"><i><img alt="" src="http://www.the-scientist.com/images/Webinars/Kelerhead.jpg" height="100" title="" width="99" /></i></span><i>Dr. Tibor Keler<br />Senior Vice President and Chief Scientific Officer<br />Celldex Therapeutics</i></div>
Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-40757299264622920392014-02-26T12:30:00.000-05:002014-03-01T12:31:42.164-05:00Hormone transport in plants deciphered<a href="http://phys.org/news/2014-02-roots-hormone-deciphered.html#jCp" style="background-color: white; color: #313d57; font-family: Arial, Helvetica, sans-serif; font-size: 14px; outline: 0px;">http://phys.org/news/2014-02-roots-hormone-deciphered.html#jCp</a><br />
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<span style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: 14px;"><i>"Plant growth is orchestrated by a spectrum of signals from hormones within a plant. A major group of plant hormones called cytokinins originate in the roots of plants, and their journey to growth areas on the stem and in leaves stimulates plant development. Though these phytohormones have been identified in the past, the molecular mechanism responsible for their transportation within plants was previously poorly understood."</i></span><br />
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<img alt="Roots to shoots: Hormone transport in plants deciphered" src="http://cdn.physorg.com/newman/gfx/news/2014/rootstoshoot.jpg" style="border: 0px; display: block; margin: 0px; padding: 0px; position: relative; z-index: 1;" /></div>
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<figcaption class="image-block-caption" style="background-color: white; color: dimgrey; font-family: Arial, Helvetica, sans-serif; font-size: 13px; margin: 0px; padding: 9px 0px 5px;"><i>Blue staining shows the distribution of the root-synthesized cytokinins. Knocking out the transporter gene impairs their translocation to leaves (right). Credit: Brookhaven National Laboratory</i></figcaption>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-640262044647446002014-02-24T12:54:00.001-05:002014-02-24T18:42:36.788-05:003D print your own micropipette ("The Biropette: a customizable, high precision pipette by tbaden" & The Straw Pipette - Thingiverse)<div class="separator" style="clear: both; text-align: left;">
The Biropette</div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEghm-H3rBESxYXvI-HMIOLs5wbknoz2s8ZGFL6gLN09YQnQxyrKW_z_AV9foetmLMDDFRupCQXkFNKoPnRkYSx2CWVRoQTQJ9rpi8vl7sbybp-e6NjJZx_qAXZOs8KFPwsV9KPAHHy0Rbw/s1600/Pipette_v15_Page_02_display_large.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEghm-H3rBESxYXvI-HMIOLs5wbknoz2s8ZGFL6gLN09YQnQxyrKW_z_AV9foetmLMDDFRupCQXkFNKoPnRkYSx2CWVRoQTQJ9rpi8vl7sbybp-e6NjJZx_qAXZOs8KFPwsV9KPAHHy0Rbw/s1600/Pipette_v15_Page_02_display_large.jpg" height="586" width="640" /></a></div>
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"Description: Accurate to a few microliters, approx. linear regulator. Customizable range and accuracy - use the customizer! Optional tip removal button ("Expunger"). No supports, designed for stability & fast printing. For details, see downloadable pdf. (<a href="https://thingiverse-production.s3.amazonaws.com/assets/ed/92/35/cc/e0/Pipette_v15.pdf">https://thingiverse-production.s3.amazonaws.com/assets/ed/92/35/cc/e0/Pipette_v15.pdf</a>) Read that before printing! You may have to use the customizer, e.g. depending on your printer accuracy, what range you want, or which type of tip you plan to use! Then you will need a bit of glue, a lab glove or similar, some tape, and 2 biro fillings including the spring. And one screw. In short, find some sort of tube that will fit a pipette tip (metal tube, PVC, anything) - then measure its diameter and put that into the customizer - alongside with all kinds of other options.*inspired by the straw pipette: Thing:64977 by kwalus."<br />
- <a href="http://www.thingiverse.com/thing:255519">http://www.thingiverse.com/thing:255519</a><br />
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Print the rack too...<br />
<a href="http://www.thingiverse.com/thing:257254">http://www.thingiverse.com/thing:257254</a><br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjgKF88HyGT2g39bphxgO9wLFxNbIR_gHhD9lU0NBzqia2Gmi6fssVqjwQaNkUUsfIqByTCgAr9Uza5Ed7ISoRrdFi0NeCNd1Vo6TLVNPXSn2OKr1pPZOmdQk1cSu7l7e-kjT98q00Eoik/s1600/Screen+Shot+2014-02-24+at+6.40.15+PM.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjgKF88HyGT2g39bphxgO9wLFxNbIR_gHhD9lU0NBzqia2Gmi6fssVqjwQaNkUUsfIqByTCgAr9Uza5Ed7ISoRrdFi0NeCNd1Vo6TLVNPXSn2OKr1pPZOmdQk1cSu7l7e-kjT98q00Eoik/s1600/Screen+Shot+2014-02-24+at+6.40.15+PM.png" height="326" width="400" /></a></div>
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The Straw Pipette:<br />
<a href="http://www.thingiverse.com/thing:64977">http://www.thingiverse.com/thing:64977</a><br />
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjXC-R1GScnY_vSxGl03SL6b2nRoXTfiahQmxluxqoVoG2tcMjBFxeFIrj9ev3elYkO0yZCjP6FOsyrP8F_2SUp-h4ZLGb9XtpwTgAS-JiK69Epkr12oDxDCUHCAyUoFZMA16G7WaT1fJE/s1600/Screen+Shot+2014-02-24+at+12.59.21+PM.png" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjXC-R1GScnY_vSxGl03SL6b2nRoXTfiahQmxluxqoVoG2tcMjBFxeFIrj9ev3elYkO0yZCjP6FOsyrP8F_2SUp-h4ZLGb9XtpwTgAS-JiK69Epkr12oDxDCUHCAyUoFZMA16G7WaT1fJE/s1600/Screen+Shot+2014-02-24+at+12.59.21+PM.png" height="475" width="640" /></a></div>
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"<span style="background-color: white; color: #343638; font-family: Helvetica, Arial, sans-serif; font-size: 15px; line-height: 20px;">Print the upper body, lower body, plunger, and two thumb gears. You will need a spring, which I got from a kids Pez dispenser for its form factor. The balloon membrane is elastic so you may get away without the spring but it is nicer to have it. You will also need a balloon, some tape, and a straw. It is designed for one particular straw diameter but I can upload others if there is demand. See the attached photos for assembly steps. I printed all the pieces at 0.1mm with 15% fill and 100% fill for the plunger."</span><br />
<br />Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-56538738255052648862014-02-20T22:36:00.001-05:002014-02-20T22:50:22.639-05:00Videos on Immunotherapy - Something very worthy of dedicating your life to! Fight the good fight!<iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/0rffK3cz0H8?rel=0" width="560"></iframe><br />
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<br />
Cancer Primer:<br />
<iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/k-6pQ2dnyLQ?rel=0" width="560"></iframe>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0tag:blogger.com,1999:blog-6349807500103086288.post-20643572546601503032014-02-20T21:58:00.002-05:002014-02-20T22:01:26.842-05:00Sciencemag.org 2013 Breakthrough of the year...<iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/9X-Cl9CMVzg?rel=0" width="560"></iframe><br />
<br />
Read the full article here. It's amazing.<br />
<a href="http://www.sciencemag.org/content/342/6165/1432.full">http://www.sciencemag.org/content/342/6165/1432.full</a>Eric Fernandezhttp://www.blogger.com/profile/13008925579336947085noreply@blogger.com0